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This SEED article is meant to explain the findings focused on cell count and differentiation for pleural, ascitic, cerebrospinal and synovial fluid as well as for CAPD. Traditionally, body fluid counts are performed by manual counting under a microscope using a haemocytometer, but laboratories now have the option of automating their manual processes using automated haematology or urinalysis analysers. This SEED summarises the advantages and disadvantages of haemocytometry and Sysmex analysers and explains briefly the XN-BF mode.
Once the analysis results have been technically validated and considered reliable, they can be looked at from a clinical angle to search for suspect results. The task of biomedical validation is to recognise abnormal or conspicuous quantita¬tive results. Based on the findings compiled by the GFHC, there is a new rule set implemented in Extended IPU looking at things such as cut-off values, assessment of previous values or additional patient information. Check out the recommendation from GFHC.
For the sake of the patient - it is of critical importance that physicians and other healthcare personnel are able to confidently rely on laboratory test results in order to make meaningful and safe decisions about the diagnosis and treatment of patients entrusted to their care.
Infection and inflammation, innate and adaptive immune response, cells that are involved in the different pathways and what the XN-Series analysers have to do with all this are the topics covered within this article.
Do you wonder if the storage and handling of QC materials influences the results? This article gives examples of how the temperature of the QC material and the mixing affects the measured results and explains also how this situations can be avoided.
The determination of the ‘erythrocyte sedimentation rate’ (ESR) is a commonly performed laboratory test with a traditional role. In this article, the mechanism of red blood cell aggregation and sedimentation is described, the standardised procedure is explained and we provide an update on the clinical interpretation of the ESR.
A short introduction to the concepts of metrological traceability and measurement uncertainty is given in the article for readers who are not familiar with them. It also includes a short description of the steps needed to evaluate uncertainty. The article further explains how traceability is assured for the Sysmex haematology calibrators and describes how the uncertainty of these calibrators was evaluated.