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This white paper intents to give an overview of the most common types of anaemia with a focus on how haematological parameters such as RET-He and other advanced RBC parameters help to distinguish different causes of anaemia. The white paper also summarises current guidelines and publications on advanced RBC parameters in order to help clinicians in choosing the appropriate treatment for the individual patient.
Haemostasis is a complex process that helps to keep the blood in a fluid state and prevent blood loss at the site of injury. While the intact endothelium of blood vessels has an anti-thrombogenic function that prevents blood coagulation, in the case of vessel wall damage, the exposed sub-endothelial components initiate the formation of a clot that will stop blood loss.
Besides the IG there is a distinct separation of an abnormal cell population with high fluorescence intensity above the monocyte and lymphocyte region. Highly fluorescent lymphocyte cells (HFLC) are observed in the DIFF channel of the Sysmex XE-series haematology analysers in an area of high fluorescence intensity.
Being diagnosed with haematologic malignancy actually happens either because the patient presents with certain symptoms or – as is becoming increasingly common – there are incidental findings during routine blood screening. This white paper describes how a complete blood count measured on Sysmex XN-Series analysers may reveal significant abnormalities and improve the incidental findings of haematologic malignancies or the relapse of cancer under treatment early on.
Doping with blood, erythropoietin or related substances is an unfair practice in sports and is performed to obtain an advantage over competing athletes. Doping control has made great progress in detecting the use of forbidden substances by employing completely new strategies that no longer rely on the detection of the banned substance itself. What is measured instead are the changes that forbidden doping practice has on haematological parameters.
Chronic kidney disease (CKD) is a severe complication in context of various civilisation diseases, such as diabetes, hypertension, and obesity. With increasing treatment cost along the progression of CKD towards end-stage renal failure (ESRF) and the need for renal replacement therapies, CKD is not only a driver of premature mortality and diminished quality of life of affected individuals, but also puts significant burden on the society and healthcare expenditures. The early detection of kidney damage through a frequent screening of risk patients could help to fight the burden of CKD. Cost-efficient routine urinalysis data could play a vital role in providing valuable information for screening, diagnosing, and monitoring of renal disorders.