Sysmex South Africa


The CS-5100 is a superb coagulation analyser. With a throughput of up to 400 tests per hour, it delivers high quality results in a very short timeframe. With its powerful multi-wavelength technology, it has 20 channels for clotting, chromogenic and immunoassays and eight for platelet aggregation with automatic stirring. The device also checks automatically for interfering substances (HIL) and can be run in random access with other assays.   

We have also focused on making the device easy to use, flexible and productive for you. Pre-analytical sample checks mean you no longer need to check manually, it offers remote access and it is easy include in larger laboratory solutions. Advanced reagent management makes use of simplified software, and an auto QC on vial change significantly diminishes the risk of errors. A great device, easy to use and as accurate as they come.


No compromise on quality

Using four different detection technologies, the CS-5100 delivers great quality analyses. With clotting, chromogenic, immunoturbimetric and platelet aggregation assays it delivers accuracy and precision for all parameters

Clotting method

The CS-5100 uses the Optical Detection Method to detect the change in turbidity of the sample-reaction mixture during the coagulation process. This is reflected in the change in scattered light intensity when fibrinogen is converted into a fibrin mesh. Light strikes the reaction mixture, after the scattered light intensity is received by a photodiode. This converts the light intensity into electrical signals and is used to find the haemostasis time. This method is used to measure prothrombin time, APTT, fibrinogen, factors and many other clotting tests.

Chromogenic method

Light with a wavelength of 405 nm passes through the sample and reagent mixture and reaches a photodiode, where the transmitted light is converted into electrical signals. The change in the intensity of this transmitted light is used to determine the change in absorbance. This measurement is used for chromogenic assays like Antithrombin and Protein C where a chromogenic substrate in presence of an activator causes the reagent mixture to change colour.

Immunoassay and platelet aggregation method

The sample-reagent mixture contains artificial particles that can aggregate when there is an antigen-antibody reaction or particles that have a natural capability to aggregate like platelets. The mixture is exposed to light of a high wavelength, and the change in light absorbance caused by the formation of aggregates is detected as the change in transmitted light. This is used for D-dimer assays and platelet aggregation assays (Von Willebrand activity, ADP, Collagen, Arachidonic Acid, Epinephrine).


Get it right before you start testing – pre-analytical sample integrity helps

Pre-analytical issues can account for as much as 70% of a clinical laboratory’s errors. Multi-wavelength scanning and sample liquid-sensing technologies detect unsuitable specimens. A pre-analytical sample integrity check tests for interfering substances in the sample – haemolysis, icterus, lipaemia – at three wavelengths: 405 nm, 575 nm and 660 nm.

A primary tube sample volume check provides assistance by identifying potential inaccuracies caused by improper sample collection, which can result in an incorrect ratio of anticoagulant to patient plasma.

Under specific conditions, the CS-5100 will automatically use the optimal wavelengths to ensure result accuracy in the presence of hemolysis, icterus or lipemia. This minimises the need for retesting and helps you deliver the highest quality results on your first test run.

Multi-wave detection - reduce your repeat tests

Using a multi-wave detection system, the CS-5100 can simultaneously measure multiple parameters using four different measurement methods: haemostasis, chromogenic, immunoassay and aggregation. The system’s photo-optical clot detection means you have several advantages compared to mechanical detection.

  • You can measure light transmittance over the entire course of clot formation, not just the end.
  • You can identify atypical reaction patterns easily and so determine the correct haemostasis reaction result for your patients with unusual in vitro clot reactions such as sepsis and DIC.
  • The clotting reactions display the complete clot signature, not just a single data point, so that you get far more detailed test information and therefore better clinical utility.

Used on a single platform, the broad range of assays allows high test throughput – up to 400 samples per hour.

Technical Specifications
Detection principles multi-wavelength detector for transmitted light at
340, 405, 575, 660 and 800 nm
Detection methods 20 channels for clotting, chromogenic and immunoassays
8 channels for platelet aggregation
Parameters up to 60 parameters can be analysed simultaneously
Throughput up to 400 tests/h

rack type, auto sampler, cap piercing functionality, initial capacity for 10 racks with 10 sample

tubes each, continuous loading possibility, separate STAT positions

direct sampling (optional) to connect the CS-5100 via its left side to a lab automation transport

Reagent holder 40 positions cooled at 10 °C
5 positions at room temperature
all positions with positive reagent identification
Reference curves multi-lot management with max. 10 curves/reagent lot
and max. 10 reagent lots/parameter
Quality control x-bar, Levey-Jennings and Westgard control
750 parameter files with max. 1,200 data points each
Data storage up to 10,000 samples

main unit*

IPU with cabinet

w x h x d [mm] / [kg]

approx. 1030 x 1280 x 1150 / 278

approx. 500 x 920 x 890 / 67

*excluding optional features, such as direct sampling, which will alter the dimensions.


Cooled reagent system – flexible and cost-efficient

In the CS-5100, we have critically addressed the usability of our haemostasis analysers – based on extensive input from users and our own knowhow. One of the results is our new, cooled reagent system with secure, in-situ barcode reading.

Reagent racks are now placed in a double-ring reagent table capable of handling a total of 40 reagent bottles maintained at 10°C. The bottles are slightly tilted to reduce dead volume and reagent waste and maximize the number of tests per vial.

One position on each reagent rack can stir reagents so that you can use reagents that require continuous mixing.

A separate reagent rack system lets you group reagents for each rack and for high sample loads - up to three vials of the same reagent. With a onboard capacity of 1000 cuvettes this delivers a long walk-away time . To reduce the risk of errors, there is an optional automatic quality control when vials are changed.  


Superior calibration and assay performance

  • Convenient batch change with maximum security
  • Accessibility for all users with standardized decision-making
  • Excellent linearity negating multiple calibrations for different assay ranges
  • Up to 12 dilution points for each calibration performed
  • Up to 10 live calibration curves per assay
  • Automatic recognition of the appropriate calibration curve.
You have a question and would like to get in touch with our experts? We look forward to receiving your enquiry.

Sysmex South Africa (Pty) Ltd

Fernridge Office Park, Block 1,

Randburg 2194

+27 (11) 329 94 80

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